Tapentadol is partly metabolized via the hepatic enzymes CYP2C9, CYP2C19, and CYP2D6 so it innately has interactions with medicines that increase or repress the exercise/expression of one or more of those enzymes, as well as with substrates of these enzymes (as a result of Levels of competition with the enzyme); https://roberto898ogx9.digitollblog.com/profile