There exists a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors within the dorsal horn to reduce afferent agony transmission and create analgesia. Hence, medications like clonidine that goal alpha-2 receptors can affect the transmission of soreness. You could possibly convey to this drug https://echobookmarks.com/story19732214/everything-about-onolidine