There's a launch of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors within the dorsal horn to minimize afferent suffering transmission and produce analgesia. As a result, medication like clonidine that goal alpha-2 receptors can affect the transmission of discomfort. Clonidine is dispersed in breast milk; https://www.proleviate.com/post/the-new-pain-killer-conolidine