Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals through the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have identified recurrent mutations in genes regulating tumor cell-microenvironment interaction... https://hubbardp642mvc9.win-blog.com/profile