Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals with the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have discovered recurrent mutations in genes regulating tumor cell-microenvironment interac... https://willaf344fzt8.hazeronwiki.com/user